Hydrochloric Acid → 2-(Piperazin-1-yl)propan-1-ol dihydrochloride

HRID 1937419Notes

Reaction equation

HRID 1937419 reaction equation
[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH:6]1C(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[CH3:4].[ClH:30]>C(O)C.C(OCC)(=O)C>[ClH:30].[ClH:30].[OH:1][CH2:2][CH:3]([N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)[CH3:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 54071300HCID 54071300, compound

Product 1

HCID 119720442-(Piperazin-1-yl)propan-1-ol dihydrochlorideYield 89%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

1-(1-Hydroxy-2-propyl)-2-triphenylmethylpiperazine (1.69 g) obtained in step 2 was dissolved in ethanol (20 ml), and a 4 mol/l hydrogen chloride solution in ethyl acetate (10 ml) was dropwise added thereto. The mixture was stirred at room temperature for 10 minutes. The solvent was distilled off under reduced pressure, the residue was suspended in ethyl ether, and the precipitated crystals were collected by filtration to give Compound L (840 mg, 89%).

Workup

  1. distillationThe solvent was distilled off under reduced pressure
  2. filtrationthe precipitated crystals were collected by filtration

Sources & evidence

ORD record
ord-c8601b29fb4040a69dddd3603f032fcd
Source dataset
uspto-grants-2002_05
Patent number
US06395738B1

Reaction notes

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