HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl 4-fluoro-2-nitrophenylmalonate → 2-(4-Fluoro-2-nitrophenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl 4-fluoro-2-nitrophenylmalonate | HCID 9838325 | — |
| Reactant | Ethyl acetate hexane | HCID 21226206 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 2-(4-Fluoro-2-nitrophenyl)acetic acid | HCID 10750492 | 89.9% |
Reaction Steps
Dimethyl 4-fluoro-2-nitrophenylmalonate (5.0 g) was refluxed in 20 mL of 6 N hydrochloric acid for 24 hours. The reaction was cooled and the white solid collected by vacuum filtration, washed with water and dried to give 3.3 g (87% yield) of 4-fluoro-2-nitrophenylacetic acid, Rf 0.6 on thin layer chromatography (ethyl acetate:hexane 1:2, silica gel).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395734B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-19fcbde58ff94ef783388d01adcad080 |
| Source note | uspto-grants-2002_05 |