HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → 5-(Morpholinosulfonyl)-2-oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | 2-oxo-2,3-dihydro-1H-indole-5-sulfonyl chloride | HCID 4962506 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(Morpholinosulfonyl)-2-oxindole | HCID 9795753 | 74.9% |
Reaction Steps
A suspension of 2.3 g of 5-chlorosulfonyl-2-oxindole and 2.2 g of morpholine in 50 mL of dichloromethane was stirred at room temperature for 3 hours. The white precipitate was collected by vacuum filtration, washed with ethyl acetate and hexane and dried under vacuum at 40° C. overnight to give 2.1 g (74% yield) of 5-(morpholinosulfonyl)-2-oxindole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395734B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-a5711a8ab14147628ac4ec0b2bc67815 |
| Source note | uspto-grants-2002_05 |