HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 54556580, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 5-Iodoindolin-2-one | HCID 9838045 | — |
| Reactant | 3-(5-formyl-4-methyl-1H-pyrrol-3-yl)propanoic acid | HCID 15160752 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54556580 | HCID 54556580 | 77.2% |
Reaction Steps
4-(2-Carboxyethyl)-2-formyl-3-methylpyrrole (90 mg), 130 mg 5-iodo-2-oxindole, and 75 L piperidine in 2 mL ethanol were heated at 95° C. for 5 hours. The reaction mixture was cooled and concentrated. The residue was suspended in 2 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven to give 162 mg (77%) of the title compound as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395734B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-349eb70ee9384dd88dd92a3cbc856303 |
| Source note | uspto-grants-2002_05 |