HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 5-(2-Chloroethyl)Oxindole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | 5-(Chloroacetyl)-1,3-dihydro-2H-indol-2-one | HCID 2060576 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | 5-(2-Chloroethyl)Oxindole | HCID 14581392 | 65% |
Reaction Steps
5-Chloroacetyl-2-oxindole (4.18 g) in 30 mL trifluoroacetic acid in an ice bath was treated with 4.65 g triethylsilane and stirred at room temperature for 3 hours. The mixture was poured into 150 mL of water and the precipitate collected by vacuum filtration, washed with 50 mL of water and dried to give 2.53 g (65% yield) of 5-(2-chloroethyl)-2-oxindole as a reddish-brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395734B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-d9d85812d6f64a1f911aadb149b44758 |
| Source note | uspto-grants-2002_05 |