HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperidine → HCID 54437410, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | 3-(5-formyl-2,4-dimethyl-1H-pyrrol-3-yl)propanoic Acid | HCID 1512520 | — |
| Reactant | 5-Methylindolin-2-one | HCID 5325716 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 54437410 | HCID 54437410 | 64.2% |
Reaction Steps
3-(2-Carboxyethyl)-2,4-dimethyl-5-formylpyrrole (97.5 mg), 74 mg 5-methyl-2-oxindole, and 75 μL piperidine in 3 mL of ethanol were heated at 95 ° C. for 5 hours. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven overnight to give 104 mg (64%) of the title compound as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395734B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-9efbf323f37a485eb2f84a9ae92db85d |
| Source note | uspto-grants-2002_05 |