HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(2-Methoxyphenyl)-1,3-dihydroindol-2-one → HCID 57181829, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(2-Methoxyphenyl)-1,3-dihydroindol-2-one | HCID 10561975 | — |
| Reactant | 3-(5-formyl-4-methyl-1H-pyrrol-3-yl)propanoic acid | HCID 15160752 | — |
| Catalyst | Piperidine | HCID 8082 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 57181829 | HCID 57181829 | 86.6% |
Reaction Steps
4-(2-Carboxyethyl)-2-formyl-3-methylpyrrole (217 mg), 239 mg 6-(2-methoxyphenyl)-2-oxindole and 3 drops piperidine in 2 mL of ethanol were heated at 90° C. overnight. The reaction mixture was cooled and concentrated. The residue was suspended in 6 N aqueous hydrochloric acid. The precipitate was filtered, washed with water to pH 6 and dried in a vacuum oven overnight to give 348 mg (86%) of the title compound as a brown solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395734B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-8d43007a6d4c4421a75869270fb8669c |
| Source note | uspto-grants-2002_05 |