反应详情

温度

190 °C

2-Phenylthioacetophenone (63.8 g) was added to 450 g of polyphosphoric acid at 100° C. and then heated further to 190° C. for three hours. The reaction was allowed to cool below 100° C. before pouring it into a mixture of ice and water. The aqueous solution was extracted with ether. The ether layer was dried with magnesium sulfate and evaporated to yield a tan, amorphous solid. The residue was crystallized from acetone-ethanol to give 35.2 g of the title compound. mp 171° C.-172° C.

1. temperatureto cool below 100° C.
2. additionbefore pouring it
3. extractionThe aqueous solution was extracted with ether
4. dry with materialThe ether layer was dried with magnesium sulfate
5. customevaporated
6. customto yield a tan, amorphous solid
7. customThe residue was crystallized from acetone-ethanol