Potassium Hydroxide → 2-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

HRID 1937667Notes

Reaction equation

HRID 1937667 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][N:23]=2)[C:16]([O:18]CC)=[O:17])[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[OH-].[K+]>C(O)C>[CH3:12][O:11][C:7]1[CH:6]=[C:5]([C:13]2[CH:14]=[C:15]([CH:21]=[CH:22][N:23]=2)[C:16]([OH:18])=[O:17])[CH:4]=[C:3]([O:2][CH3:1])[C:8]=1[O:9][CH3:10]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 16125879Ethyl 2-(3,4,5-trimethoxyphenyl)pyridine-4-carboxylate

Product 1

HCID 120434852-(3,4,5-Trimethoxyphenyl)pyridine-4-carboxylic acid

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of ethyl 2-(3,4,5-trimethoxyphenyl)isonicotinate (3.17 g) in ethanol (40 mL) was added 10% potassium hydroxide (2.42 g). The mixture was stirred at room temperature for 5 hours and evaporated. Water was added to the residue and pH was adjusted to 7. White precipitates of the title compound were collected by filtration and the compound was used for next step without further purification.

Workup

  1. customevaporated
  2. additionWater was added to the residue and pH
  3. customWhite precipitates of the title compound
  4. filtrationwere collected by filtration
  5. customthe compound was used for next step without further purification

Sources & evidence

ORD record
ord-54ea64af05b444928c6860e09896b430
Source dataset
uspto-grants-2002_05
Patent number
US06395753B1

Reaction notes

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