Piperonylamine → [2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidone

HRID 1937672Notes

Reaction equation

HRID 1937672 reaction equation
O.Cl.[NH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1.Cl[CH2:11][C:12]1[CH:17]=[CH:16][N:15]=[C:14]([C:18]2[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH3:27])=[C:20]([O:28][CH3:29])[CH:19]=2)[CH:13]=1>>[CH3:25][O:24][C:22]1[CH:23]=[C:18]([C:14]2[CH:13]=[C:12]([CH2:11][N:3]3[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]3)[CH:17]=[CH:16][N:15]=2)[CH:19]=[C:20]([O:28][CH3:29])[C:21]=1[O:26][CH3:27]

Participants

3

Reactant 2

HCID 2723901PiperonylamineHCID 120192374-Chloromethyl-2-(3,4,5-trimethoxyphenyl) pyridine

Product 1

HCID 22557811[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidone

Procedure

4-Piperidone hydrochloride monohydrate (3.07 g) and 4-chloromethyl-2-(3,4,5-trimethoxyphenyl)pyridine (2.94 g) were coupled by the same manner as described in Example 2 to give the title compound.

Sources & evidence

ORD record
ord-f164a9c0ef5d41c591ae777b420028cb
Source dataset
uspto-grants-2002_05
Patent number
US06395753B1

Reaction notes

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