HCID 22557787, compound → HCID 22558017, compound

HRID 1937679Notes

Reaction equation

HRID 1937679 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10]2[CH:15]=[C:14]([CH2:16][N:17]3[CH2:22][CH2:21][CH:20]([NH:23][CH3:24])[CH2:19][CH2:18]3)[CH:13]=[CH:12][N:11]=2)=[CH:4][C:3]=1[O:25][CH3:26].[Cl:27][C:28]1[C:33]([O:34][CH3:35])=[CH:32][C:31]([C:36]2[CH:41]=[C:40]([CH2:42]Cl)[CH:39]=[CH:38][N:37]=2)=[CH:30][C:29]=1[O:44][CH3:45]>>[ClH:1].[ClH:27].[ClH:1].[ClH:1].[Cl:1][C:2]1[C:7]([O:8][CH3:9])=[CH:6][C:5]([C:10]2[CH:15]=[C:14]([CH2:16][N:17]3[CH2:18][CH2:19][CH:20]([N:23]([CH2:42][C:40]4[CH:39]=[CH:38][N:37]=[C:36]([C:31]5[CH:32]=[C:33]([O:34][CH3:35])[C:28]([Cl:27])=[C:29]([O:44][CH3:45])[CH:30]=5)[CH:41]=4)[CH3:24])[CH2:21][CH2:22]3)[CH:13]=[CH:12][N:11]=2)=[CH:4][C:3]=1[O:25][CH3:26]

Participants

3

Reactant 2

HCID 22557787HCID 22557787, compoundHCID 22557933HCID 22557933, compound

Product 1

HCID 22558017HCID 22558017, compound

Procedure

1-[[2-(4-chloro-3,5-dimethoxyphenyl)pyridin-4-yl]methyl]-4-methylamino-piperidine (195 mg) and 2-(4-chloro-3,5-dimethoxyphenyl)-4-chloromethylpyridine (152 mg) were condensed in the same manner as described in Example 2. A free base obtained was converted to a tetrahydrochloride giving yellow powder.

Workup

  1. customcondensed in the same manner
  2. customA free base obtained

Sources & evidence

ORD record
ord-12b076de3d9b4b1e8220c91d24cdde7c
Source dataset
uspto-grants-2002_05
Patent number
US06395753B1

Reaction notes

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