P-Anisidine → HCID 22557950, compound

HRID 1937692Notes

Reaction equation

HRID 1937692 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:15]2[CH:20]=[C:19]([CH2:21][N:22]3[CH2:27][CH2:26][C:25](=O)[CH2:24][CH2:23]3)[CH:18]=[CH:17][N:16]=2)[CH:6]=[C:7]([O:13][CH3:14])[C:8]=1[O:9][CH:10]([CH3:12])[CH3:11].[CH3:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=1>>[CH3:29][O:30][C:31]1[CH:36]=[CH:35][C:34]([NH:37][CH:25]2[CH2:26][CH2:27][N:22]([CH2:21][C:19]3[CH:18]=[CH:17][N:16]=[C:15]([C:5]4[CH:6]=[C:7]([O:13][CH3:14])[C:8]([O:9][CH:10]([CH3:11])[CH3:12])=[C:3]([O:2][CH3:1])[CH:4]=4)[CH:20]=3)[CH2:23][CH2:24]2)=[CH:33][CH:32]=1

Participants

3

Reactant 2

HCID 7732P-AnisidineHCID 22557797HCID 22557797, compound

Product 1

HCID 22557950HCID 22557950, compound

Procedure

1-[[2-(3,5-dimethoxy-4-isopropoxyphenyl)pyridin-4-yl]methyl]-4-piperidone (350 mg) and p-anisidine (123 mg) were condensed in the same manner as described in Preparation Example 37 to give the title compound.

Workup

  1. customcondensed in the same manner
  2. customas described in Preparation Example 37

Sources & evidence

ORD record
ord-43f63176a66e4a12a7cba10b97cb23b4
Source dataset
uspto-grants-2002_05
Patent number
US06395753B1

Reaction notes

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