HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3,4,5-Trimethoxyphenyl)benzyl chloride → 4-[N-benzyl-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine trihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3,4,5-Trimethoxyphenyl)benzyl chloride | HCID 12021157 | — |
| Reactant | 4-Benzylamino-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine | HCID 12043484 | — |
| Product | 4-[N-benzyl-N-[3-(3,4,5-trimethoxyphenyl)benzyl]amino]-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine trihydrochloride | HCID 22558064 | — |
Reaction Steps
4-Benzylamino-1-[[2-(3,4,5-trimethoxyphenyl)pyridin-4-yl]methyl]piperidine (134 mg) and 3-(3,4,5-trimethoxyphenyl)benzyl chloride (114 mg) were condensed by the same manner as described in Example 9. Yellow oil of a free base was converted to a trihydrochloride which gave the title compound as yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395753B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-fca41d3f23f74736bffb24d8adb249c9 |
| Source note | uspto-grants-2002_05 |