1,3-Benzodioxol-5-amine → 4-(3,4-Methylenedioxyphenylamino)-1-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]piperidine

HRID 1937709Notes

Reaction equation

HRID 1937709 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:13]2[CH:18]=[C:17]([CH2:19][N:20]3[CH2:25][CH2:24][C:23](=O)[CH2:22][CH2:21]3)[CH:16]=[CH:15][N:14]=2)[CH:6]=[C:7]([O:11][CH3:12])[C:8]=1[O:9][CH3:10].[CH2:27]1[O:36][C:35]2[CH:34]=[CH:33][C:31]([NH2:32])=[CH:30][C:29]=2[O:28]1>>[CH2:27]1[O:36][C:35]2[CH:34]=[CH:33][C:31]([NH:32][CH:23]3[CH2:22][CH2:21][N:20]([CH2:19][C:17]4[CH:16]=[CH:15][N:14]=[C:13]([C:5]5[CH:6]=[C:7]([O:11][CH3:12])[C:8]([O:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=5)[CH:18]=4)[CH2:25][CH2:24]3)=[CH:30][C:29]=2[O:28]1

Participants

3

Reactant 2

HCID 843101,3-Benzodioxol-5-amineHCID 22557811[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidone

Product 1

HCID 120434874-(3,4-Methylenedioxyphenylamino)-1-[[2-(3,4,5-trimethoxyphenyl) pyridin-4-yl]methyl]piperidine

Procedure

1-[[2-(3,4,5-Trimethoxyphenyl)pyridin-4-yl]methyl-4-piperidone (1.40 g) and 3,4-methylenedioxyaniline (646 mg) were treated in the same manner as described in Preparation Example 29 to give the title compound.

Workup

  1. customas described in Preparation Example 29

Sources & evidence

ORD record
ord-1706269f56f5427da367f12c2af0b357
Source dataset
uspto-grants-2002_05
Patent number
US06395753B1

Reaction notes

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