2-Chloropyridine → HCID 54335591, compound

HRID 1937734Notes

Reaction equation

HRID 1937734 reaction equation
[NH2:1][CH2:2][C@@H:3]([OH:6])[CH2:4][CH3:5].CC(C)([O-])C.[K+].Cl[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][N:15]=1>>[N:15]1[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=1[NH:1][CH2:2][C@@H:3]([OH:6])[CH2:4][CH3:5]

Participants

4

Reactant 3

HCID 79772-ChloropyridineHCID 6995554(2S)-1-Amino-2-butanolHCID 23665647Potassium tert-butoxide

Product 1

HCID 54335591HCID 54335591, compound

Procedure

(S)-1-Aminobutan-2-ol (35 millimoles), potassium tertiary butoxide (77 millimoles) and 2-chloropyridine (38.5 millimoles) were used in a similar manner to Example 1(a) to obtain the title compound, [α]D26=+10° (1.12% concentration in trichloromethane).

Workup

  1. customto obtain
  2. concentrationthe title compound, [α]D26=+10° (1.12% concentration in trichloromethane)

Sources & evidence

ORD record
ord-80e6733de6204df68c4a0a016cbca240
Source dataset
uspto-grants-2002_05
Patent number
US06395902B1

Reaction notes

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