Acetic Acid → 2-Chloro-5-fluoronicotinic acid

HRID 193775Notes

Reaction equation

HRID 193775 reaction equation
[CH3:16][C:17](=[O:18])[OH:19].[CH3:1][OH:2].[Cl:3][c:4]1[c:5]([C:6](=[O:7])[OH:8])[cH:9][c:10]([F:14])[c:11]([Cl:13])[n:12]1.[Zn:15]>>[Cl:3][c:4]1[c:5]([C:6](=[O:7])[OH:8])[cH:9][c:10]([F:14])[cH:11][n:12]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 887MethanolHCID 23994ZincHCID 27336592,6-Dichloro-5-fluoronicotinic acid

Product 1

HCID 114352432-Chloro-5-fluoronicotinic acid

Sources & evidence

ORD record
ord-589953f8c4ea4746b5c6bb423f08e83c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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