Trimethyl orthoformate → HCID 11356486, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred mixture of 17.7 g methyl-trans-3-methoxyacrylate and 32.3 g trimethyl ortho formate was added 1.0 g PhSnCl3. The mixture was heated to 60° C. for 24 hours, cooled to room temperature and 5.00 g anhydrous sodium carbonate were added. After stirring for 2 hours, the mixture was filtered and the filter-cake washed with trimethyl ortho formate. Fractional distillation gave 11.6 g colorless liquid (69% of theoretical based on converted methyl-trans-3-methoxyacrylate) of boiling point 1000° C./4 mm Hg, A GC-analysis of the liquid revealed an assay of >99% (FID-detection).

Provenance & Evidence