HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 2-Bromo-5-methoxybenzyl bromide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 1-Bromo-4-methoxy-2-methylbenzene | HCID 117915 | — |
| Catalyst | Azobisisobutyronitrile | HCID 6547 | — |
| Solvent | 1,1-Dichloroethane | HCID 6365 | — |
| Product | 2-Bromo-5-methoxybenzyl bromide | HCID 3525951 | 64% |
Reaction Steps
To a solution of 2-bromo-5-methoxytoluene (50 g, 0.25 mol) in dichloroethane (375 ml), N-bromosuccinimide (48.8 g, 0.275 mol) and AIBN (1.36 g) were added and the reaction was refluxed for 4 h. The cooled solution was filtered and the solvent was evaporated to give a weight of 44.8 g crude 1-Bromo-2-bromomethyl-4-methoxy-benzene (64% yield). This compound was used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395911B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-f980ff73bd2d4899a6d0a3f6e72613d1 |
| Source note | uspto-grants-2002_05 |