HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 22461733, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | Methyl 4-methoxysalicylate | HCID 79523 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 22461733 | HCID 22461733 | 100.5% |
Reaction Steps
A solution of 2-methoxycarbonyl-5-methoxyphenol (34.1 g, 0.187 mol), 2-nitrofluorobenzene (19.7 mL, 0.187 mol), and K2CO3 (65 g, 0.467 mol) in DMF (200 mL) was heated at 110° C. for 18 h. The solution was diluted with water (200 mL) and extracted with EtOAc. The EtOAc layer was concentrated to give the crude title compound (57 g)which was used as is for the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06395919B1 |
| Source dataset | uspto-grants-2002_05 |
| ORD ID | ord-11d774f026004164b3b3b409bf240df1 |
| Source note | uspto-grants-2002_05 |