(R)-(-)-Glycidyl-4-nitrobenzenesulfonate → HCID 88171366, compound

HRID 1937785Notes

Reaction equation

HRID 1937785 reaction equation
[C:1]([C:3]1[C:8]([OH:9])=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])#[N:2].S(C1C=CC([N+]([O-])=O)=CC=1)(O[CH2:22][C@@H:23]1[O:25][CH2:24]1)(=O)=O>>[CH2:22]([O:9][C:8]1[CH:7]=[CH:6][CH:5]=[C:4]([CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:3]=1[C:1]#[N:2])[C@@H:23]1[O:25][CH2:24]1

Participants

3

Reactant 2

HCID 14292098(R)-(-)-Glycidyl-4-nitrobenzenesulfonateHCID 22461692HCID 22461692, compound

Product 1

HCID 88171366HCID 88171366, compoundYield 80.2%

Procedure

Using the method of example 1(a), supra, ethyl 4-(2-cyano3-hydroxyphenyl)butanoate (1.9 g, 7.33 mmol) and (R)-glycidyl nosylate (1.78 g, 7.6 mmol) were used to prepare 1.70 g (80%) of the title compound as a white solid.

Sources & evidence

ORD record
ord-c1f25ff8c2d14b50b97a3a948a0279e1
Source dataset
uspto-grants-2002_05
Patent number
US06395919B1

Reaction notes

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