Hexachloroethane → HCID 22721725, compound

Participants

Reaction Steps

Hexachloroethane (445 mg, 1.87 mmol) was dissolved in 5 mL CH3CN. A solution of pyridine-2-carboxylic acid (1-formyl-3-methylbutyl)amide (137.5 mg, 0.625 mmol) in 2 mL CH3CN was added followed by triethylamine (375 mg, 3.75 mmol) and triphenylphosphine (491 mg, 1.87 mmol). The resulting mixture was stirred for ½ h, poured into brine, and extracted with 2×25 mL EtOAc. The combined extracts were washed with 1×50 mL brine, dried with Na2SO4 and evaporated to 665 mg of a tan solid which was flash chromatographed through SiO2 (20%-35% hexane/EtOAc) yielding 100 mg (76%) of the title compound as an amber oil, MS (ES) 203 (M+).

Provenance & Evidence