HCID 178501508, compound → HCID 131723229, compound

Participants

Reaction Steps

(S)-Cyclohexyl-{2-(R,S)-dimethylcarbamoyl-3-[4-(N-hydroxycarbamimidoyl)-phenyl]-propionylamino}-acetic acid methyl ester (13 g, 30 mmol) was dissolved in acetic acid (150 ml). After addition of palladium on charcoal (10%, 100 mg) the mixture was hydrogenated at 50° C. for 9 hours. The catalyst was filtered off, the solvent evaporated and the residue dissolved in water and lyophilized. Yield: 14.3 g (100%); MS m/z: 417.4 (M+H)+.

Provenance & Evidence