Hydroxylamine → HCID 178501507, compound

Participants

Reaction Steps

A suspension of [2-(R,S)-benzylcarbamoyl-3-(4-cyano-phenyl)-propionylamino]-(S)-cyclohexyl-acetic acid methyl ester (9 g, 19.5 mmol) and hydroxylamine (3.22 g, 97.5 mmol) in ethanol (180 ml) was heated to reflux for 4 hours. The reaction mixture was cooled to room temperature, evaporated in vacuo, solved in ethanol and poured in ice-water. The precipitate was collected by suction and dried at 50° C. in vacuo to give 7.9 g (82%) of the desired product. mp.: 101-104° C., MS m/z: 495 (M+H)+.

Provenance & Evidence