Ethanol → 4-[4-(4-Trifluoromethoxyphenyl)piperazin-1-yl]phenol

HRID 193782Notes

Reaction equation

HRID 193782 reaction equation
[CH3:48][CH2:49][OH:50].[O:1]1[CH2:2][CH2:3][CH2:4][CH2:5][CH:6]1[O:7][c:8]1[cH:9][cH:10][c:11]([N:14]2[CH2:15][CH2:16][N:17]([c:20]3[cH:21][cH:22][c:23]([O:26][C:27]([F:28])([F:29])[F:30])[cH:24][cH:25]3)[CH2:18][CH2:19]2)[cH:12][cH:13]1.[c:31]1([CH3:32])[cH:33][cH:34][c:35]([S:36]([O-:37])(=[O:38])=[O:39])[cH:40][cH:41]1.[nH+:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1>>[OH:7][c:8]1[cH:9][cH:10][c:11]([N:14]2[CH2:15][CH2:16][N:17]([c:20]3[cH:21][cH:22][c:23]([O:26][C:27]([F:28])([F:29])[F:30])[cH:24][cH:25]3)[CH2:18][CH2:19]2)[cH:12][cH:13]1

Participants

5

Reactant 4

HCID 702EthanolHCID 85570p-ToluenesulfonateHCID 4989215PyridiniumHCID 230811991-[4-(Tetrahydropyran-2-yloxy)phenyl]-4-(4-trifluoromethoxyphenyl)piperazine

Product 1

HCID 694797194-[4-(4-Trifluoromethoxyphenyl)piperazin-1-yl]phenol

Sources & evidence

ORD record
ord-062be68b60d847c8b2fc5409c61fdca5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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