Acetonitrile → HCID 131723241, compound

Participants

Reaction Steps

22.1 g (44.8 mmol) of the above [2-(R,S)-(Benzyl-methyl-carbamoyl)-3-(4-carbamimidoyl-phenyl)-propionylamino]-(S)-cyclohexyl-acetic acid methyl ester was suspended in water/concentrated hydrochloric acid (1/1, 40 ml) and acetonitrile (40 ml) was added to give a solution. The reaction mixture was stirred at room temperature for 7 days. The reaction mixture was concentrated in vacuo and the residue was purified on silica gel with dichloromethane/methanol/TFA as solvent to give the desired product.

Provenance & Evidence