HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1938158Generated: November 2, 2026
Sodium Acetate → 2-Acetoxy-2',4'-difluoroacetophenone
https://huagongshe.com/reaction/1938158
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Acetate | HCID 517045 | — |
| Reactant | 2-Chloro-1-(2,4-difluorophenyl)ethanone | HCID 588083 | — |
| Catalyst | 2-Naphthylalanine | HCID 185915 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Acetoxy-2',4'-difluoroacetophenone | HCID 15253026 | 92.2% |
Reaction Steps
Add 191 g of 2-chloro-2',4'-difluoroacetophenone (Aldrich Chemical Co.) to a mixture of 246 g of sodium acetate, 3 g of Nal, and 3L of DMF. Stir the mixture at 20° C. for 18 hr. then concentrate it to 1L. Pour the residue into 6L of cold dilute aqueous HCl and extract with EtOAc. Wash the extract with brine, dry it over anhydrous Na2SO4, filter the so-formed mixture, and evaporate the filtrate to leave a residue. Chromatograph the residue on silica gel, eluting with CH2Cl-2-hexane to obtain 198 g of the title compound. ##STR103##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05693626 |
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| Source dataset | uspto-grants-1997_12 |
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| ORD ID | ord-2e3392d773f04e7e88dd7a98b49de6a2 |
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| Source note | uspto-grants-1997_12 |
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