HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1938162Generated: November 1, 2026
Benzoic acid, 2-amino-5-iodo- → 6-iodo-2H-3,1-benzoxazine-2,4(1H)-dione
https://huagongshe.com/reaction/1938162
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoic acid, 2-amino-5-iodo- | HCID 72911 | — |
| Reactant | Triphosgene | HCID 94429 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 6-iodo-2H-3,1-benzoxazine-2,4(1H)-dione | HCID 294480 | 212.5% |
Reaction Steps
10 g (0.038 mol) of 5-iodoanthranilic acid were dissolved in 180 ml of THF, and 3.76 g (0.0127 mol) of bis(trichloromethyl) carbonate dissolved in 20 ml of THF were added. The mixture was then stirred at room temperature for 1 h and at 50° C. for 2 h. After cooling, the precipitate was filtered off with suction and dried. 7.8 g (71%) of 5-iodoisatoic anhydride were obtained as white crystals.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05693637 |
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| Source dataset | uspto-grants-1997_12 |
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| ORD ID | ord-e013c49352ad4b38ab306c601d7622d6 |
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| Source note | uspto-grants-1997_12 |
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