Triethylamine → HCID 21469077, compound

Participants

Reaction Steps

4.6 g of 2-amino-5-iodo-N-(2-methoxycarbonylethyl)benzamide were introduced with 2.66 g (26.3 mmol) of triethylamine into 50 ml of dichloromethane and, under nitrogen, 1.21 g (4.1 mmol) of bis(trichloromethyl) carbonate dissolved in 15 ml of dichloromethane were added dropwise. The mixture was refluxed for 2 h and, after cooling, added to ice-water. The aqueous phase was extracted with dichloromethane, and the organic phase was dried and concentrated. 3.64 g (74%) of 6-iodo-3-(2-methoxycarbonylethyl)quinazoline-2,4-dione [RF 0.52 (ethyl acetate/n-heptane, 2:1)] were obtained as a yellowish solid.

Provenance & Evidence