1-Pentene → HCID 67726848, compound

Participants

Reaction Steps

1.09 g (1.8 mmol) of 6-iodo-3-(2-methoxycarbonylethyl)-1-(N-t-butylcarbamoyl-3-indolylmethyl)quinazoline-2,4-dione and 0.75 g (5.4 mmol) of potassium carbonate were introduced in 15 ml of DMF, and 0.63 g (9.0 mmol) of 1-pentene, 0.58 g (1.8 mmol) of tetrabutylammonium bromide and 10 mg of palladium acetate were added. The mixture was stirred at room temperature for 48 h and then concentrated under reduced pressure. The crude product was chromatographed on silica gel, eluent dichloromethane (2% methanol). 0.69 g (70%) of product, RF 0.12 (dichloromethane+2% methanol) was obtained.

Provenance & Evidence