4,6-Dichloro-2-(methylthio)-5-nitropyrimidine → 2-Methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine

HRID 1938183Notes

Reaction equation

HRID 1938183 reaction equation
[CH3:1][S:2][C:3]1[N:8]=[C:7](Cl)[C:6]([N+:10]([O-:12])=[O:11])=[C:5]([Cl:13])[N:4]=1.[CH2:14]([O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[CH:24][C:23]=1[OH:30])[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>>[CH3:1][S:2][C:3]1[N:4]=[C:5]([Cl:13])[C:6]([N+:10]([O-:12])=[O:11])=[C:7]([O:30][C:23]2[CH:24]=[C:25]([C:28]#[N:29])[CH:26]=[CH:27][C:22]=2[O:21][CH2:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[N:8]=1

Participants

3

Reactant 2

HCID 113454584,6-Dichloro-2-(methylthio)-5-nitropyrimidineHCID 154534514-(Benzyloxy)-3-hydroxybenzonitrile

Product 1

HCID 221029862-Methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine

Procedure

In a similar manner, 2-methylthio-4,6-dichloro-5-nitropyrimidine, a compound of formula (A), was treated with 2-benzyloxy-5-cyanophenol to yield 2-methylthio-4-chloro-5-nitro-6-(2-benzyloxy-5-cyanophenoxy)pyrimidine, a compound of formula (K).

Sources & evidence

ORD record
ord-c140f6428da84d298d5973de8eef8299
Source dataset
uspto-grants-1997_12
Patent number
US05693641

Reaction notes

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