Hydrochloric Acid → HCID 70299391, compound

Participants

Reaction Steps

The above ester (0.74 g, 1.8 mmol) was dissolved in ethanol (25 ml) and 40% sodium hydroxide (6 ml) was added. The mixture was heated at reflux for 1 h. 10% Hydrochloric acid (25 ml) was added followed by dichloromethane (150 ml). The phases were separated and the organic phase was washed with water, dried (NaSO4) and the solvent was evaporated in vacuo to give 0.6 g of the title compound as a solid. M.p. 150°-160° C. A sample was dissolved in acetone and precipitated with diethyl ether. The solid formed was isolated by filtration and dried in vacuo.

Provenance & Evidence