HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → 2,4,5,6-Tetrahydro-2-methyl-6-(4-aminobenzoyl)-pyrazolo[4,3-d][1]benzazepine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 2,4,5,6-Tetrahydro-2-methyl-6-(4-nitrobenzoyl)-pyrazolo[4,3-d][1]benzazepin | HCID 57113393 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2,4,5,6-Tetrahydro-2-methyl-6-(4-aminobenzoyl)-pyrazolo[4,3-d][1]benzazepine | HCID 53890129 | 90.5% |
Reaction Steps
A mixture of 0.520 g of 2,4,5,6-tetrahydro-2-methyl-6-(4-nitrobenzoyl)pyrazolo[4,3-d][1]benzazepine, 118 μl of anhydrous hydrazine and 52 mg of 10% palladium-on-carbon in 30 ml of absolute ethyl alcohol is heated at reflux for 1 hour. The reaction mixture is filtered through diatomaceous earth and the cake washed with 100 ml of methyl alcohol and 1:1 chloroform-methyl alcohol to give 430 mg of the desired product as off-white crystals. CIMS(CH4)MH+ =319.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693635 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-a018fc119a724d8d99f3cb18e42bf001 |
| Source note | uspto-grants-1997_12 |