HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylbenzoyl chloride → N-[4-(6,11-Dihydro-dibenzo[b,e]azepine-5-carbonyl)-phenyl]-2-methyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylbenzoyl chloride | HCID 70276 | — |
| Reactant | 5-(4-Aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine | HCID 15410467 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-[4-(6,11-Dihydro-dibenzo[b,e]azepine-5-carbonyl)-phenyl]-2-methyl-benzamide | HCID 15307968 | 77.1% |
Reaction Steps
As described for Example 9, 0.942 g (3 mmol) of 5-(4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine is reacted with 0.52 g (3.3 mmol) of 2-methylbenzoyl chloride in 20 ml of dichloromethane. The product is triturated with hexane-ethyl acetate to give 1.0 g of yellow crystals, m.p. 198°-203° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693635 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-8c018c2f0c0140b8a775890b3d0d9396 |
| Source note | uspto-grants-1997_12 |