HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-N-methyl-2-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 6,11-Dihydro-5H-dibenz[b,e]azepine | HCID 67974 | — |
| Reactant | 4-(N-methyl-N-(2-methylbenzoyl)amino]benzoyl chloride | HCID 21837092 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-[4-[(6,11-Dihydro-5H-dibenz[b,e]azepin-5-yl)carbonyl]phenyl]-N-methyl-2-methylbenzamide | HCID 15307995 | 78.1% |
Reaction Steps
A mixture of 0.291 g of 6,11-dihydro-5H-dibenz[b,e]azepine, 0.518 g of 4-[N-methyl-N-(2-methylbenzoyl)amino]benzoyl chloride and 0.182 g of triethylamine in 10 ml of tetrahydrofuran is stirred at room temperature for 2 hours. The solvent is removed, the residue diluted with water and extracted with dichloromethane. The extract is washed with 1N HCl water, 1M NaHCO3, brine and dried (Na2SO4). The solution is passed through a thin pad of hydrous magnesium silicate. The filtrate is concentrated and chilled to give 0.52 g of crystals, m.p. 160°-170° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693635 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-0d220e28778d4166b2e97166aace062c |
| Source note | uspto-grants-1997_12 |