HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 44212557, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Fluoro-2-methylbenzoyl chloride | HCID 2737383 | — |
| Reactant | HCID 53937637 | HCID 53937637 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 44212557 | HCID 44212557 | 95.3% |
Reaction Steps
A mixture of 0.79 g of 5-(3-methoxy-4-aminobenzoyl)-6,11-dihydro-5H-dibenz[b,e]azepine, 0.40 g of N,N-diisopropylethylamine and 0.55 g of 2-methyl-5-fluorobenzoyl chloride in 25 ml of methylene chloride is stirred at room temperature for 18 hours. The reaction mixture is washed with water and saturated NaHCO3, dried (Na2SO4) and passed through a short pad of hydrous magnesium silicate. Hexane is added at the boil to the filtrate to give 1.05 g of the desired product as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693635 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-188041b6589e4823ae934521d827dead |
| Source note | uspto-grants-1997_12 |