Sodium Acetate → HCID 140385019, compound

HRID 1938337Notes

Reaction equation

HRID 1938337 reaction equation
Br[CH:2]([CH2:7][C:8]1[CH:9]=[N:10][C:11]2[C:16]([CH:17]=1)=[CH:15][CH:14]=[C:13]([O:18][CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[C:26]([F:29])([F:28])[F:27])[CH:12]=2)[C:3]([O:5]C)=O.[NH2:30][C:31]([NH2:33])=[S:32].C([O-])(=O)C.[Na+]>C(O)C>[NH:30]=[C:31]1[NH:33][C:3](=[O:5])[CH:2]([CH2:7][C:8]2[CH:9]=[N:10][C:11]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[C:13]([O:18][CH2:19][C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=2[C:26]([F:27])([F:28])[F:29])[CH:12]=3)[S:32]1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 21469305HCID 21469305, compound

Product 1

HCID 140385019HCID 140385019, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (10 mL) was dissolved the crude residue (720 mg) of methyl 2-bromo-3-[7-(2-trifluoromethylbenzyloxy)-3-quinolyl]propionate. The solution was heated under reflux for 5 hours after addition of thiourea (117 mg, 1.53 mmol.) and sodium acetate (126 mg, 1.53 mmol.).

Workup

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 5 hours

Sources & evidence

ORD record
ord-9f3706969426442a9824b7700042c120
Source dataset
uspto-grants-1997_12
Patent number
US05693651

Reaction notes

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