Sodium Acetate → HCID 140385021, compound

HRID 1938341Notes

Reaction equation

HRID 1938341 reaction equation
Br[CH:2]([CH2:7][C:8]1[CH:9]=[N:10][C:11]2[C:16]([CH:17]=1)=[CH:15][CH:14]=[C:13]([O:18][CH2:19][C:20]1[N:21]=[C:22]([C:26]3[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=3)[O:23][C:24]=1[CH3:25])[CH:12]=2)[C:3]([O:5]C)=O.[NH2:32][C:33]([NH2:35])=[S:34].C([O-])(=O)C.[Na+]>C(O)C>[CH3:25][C:24]1[O:23][C:22]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)=[N:21][C:20]=1[CH2:19][O:18][C:13]1[CH:12]=[C:11]2[C:16]([CH:17]=[C:8]([CH2:7][CH:2]3[S:34][C:33](=[NH:32])[NH:35][C:3]3=[O:5])[CH:9]=[N:10]2)=[CH:15][CH:14]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 21469329HCID 21469329, compound

Product 1

HCID 140385021HCID 140385021, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

In ethanol (10 mL) was dissolved the crude residue (300 mg) of methyl 2-bromo-3-[7-(5-methyl-2-phenyl-4-oxazolylmethoxy)-3-quinolyl]propionate. The solution was heated under reflux for 5 hours after addition of thiourea (47 mg, 0.62 mmol.) and sodium acetate (51 mg, 0.62 mmol.).

Workup

  1. temperatureThe solution was heated
  2. temperatureunder reflux for 5 hours

Sources & evidence

ORD record
ord-0fafe679f46e46e59350d6fdf1579f6b
Source dataset
uspto-grants-1997_12
Patent number
US05693651

Reaction notes

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