HCID 86751688, compound → HCID 86751689, compound

Participants

Reaction Steps

The above 5-[[7-(methylphenylamino)methyl-3-quinolyl]methylene]thiazolidine-2,4-dione (164 mg, 0.47 mmol.) was dissolved in 1,4-dioxane (5 mL), and hydrogenated at room temperature for 27 hours after addition of platinum oxide (170 mg). The reaction mixture was filtered over Celite® to remove the catalyst. The residue was washed with methanol. The methanol washings and the filtrate were combined. Then, the solvent was distilled off under reduced pressure. The residue was purified by thin layer chromatography (hexane/ethyl acetate=1/1), to give the desired compound as a yellow amorphous product (39.1 mg, yield: 22%).

Provenance & Evidence