Hydrochloric Acid → HCID 21469272, compound

Participants

Reaction Steps

In ethanol (1.5 mL) were suspended ethyl 2-hydroxy-3-(7-benzyloxy-3-quinolyl)propionate (162 mg, 0.461 mmol.), urea (48.7 mg, 0.804 mmol.) and sodium methoxide (28% methanolic solution, 0.12 mL, 0.622 mmol.). The resulting suspension was stirred for one hour at room temperature, and then heated under reflux for 4 hours. The reaction mixture was cooled, and neutralized by addition of saturated aqueous sodium hydrogen carbonate solution after addition of 1N hydrochloric acid (1.0 mL) and water (2.0 mL). Insolubles were collected, washed with ethyl acetate and ether, and dried under reduced pressure, to give 110 mg of the desired compound as white crystalline powder (yield 66%).

Provenance & Evidence