HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phthalimide → 2-Phthalimidomethyl-8-methoxy-chroman
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phthalimide | HCID 6809 | — |
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 2-Hydroxymethyl-8-methoxy-chroman | HCID 23431818 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Phthalimidomethyl-8-methoxy-chroman | HCID 21467365 | 80% |
Reaction Steps
By reacting the compound from Example II with phthalimide in the presence of equimolar amounts of triphenylphosphane and diethyl azodicarboxylate in tetrahydrofuran, the desired product is obtained in 80% yield in the form of a syrup, which is further reacted directly. Rf =0.46 (toluene/ethyl acetate 3:1)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693653 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-e9b82c0abae24dfa9165dfa3e757305d |
| Source note | uspto-grants-1997_12 |