3-(4-Piperidinyl)-1H-indole → HCID 131720346, compound

Participants

Reaction Steps

1.2 g of 3-(4-chlorobutyl)-5-methoxyindole [obtainable by reaction of 5-methoxyindole with 4-chlorobutyryl chloride to give 3-(4-chlorobutyryl)-5-methoxyindole and subsequent reduction with diborane] and 1.0 g of 4-(indol-3-yl)piperidine [obtainable by reaction of N-BOC-4-piperidone with indole, subsequent dehydration and hydrogenation of the resulting double bond, and removal of the protective group] are dissolved in 200 ml of acetonitrile and the mixture is stirred at room temperature for 8 hours. Working-up in a conventional manner gives 3-[1-(4-(5-methoxyindol-3-yl)-butyl)-4-piperidyl]indole, hydrochloride, m.p. 138°-141° (dec.).

Provenance & Evidence