HCID 21469392, compound → HCID 21469407, compound

HRID 1938359Notes

Reaction equation

HRID 1938359 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[C:30]([C:33]([O:35]C)=[O:34])[CH:31]=3)[NH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:4]>[OH-].[K+]>[C:3]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:19][CH2:20][CH:21]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[C:30]([C:33]([OH:35])=[O:34])[CH:31]=3)[NH:26][CH:25]=2)[CH2:22][CH2:23]1)([OH:4])=[O:2]

Participants

3

Reactant 1

HCID 21469392HCID 21469392, compound

Product 1

HCID 21469407HCID 21469407, compound

Reagents, catalysts & solvents 1

HCID 14797Potassium HydroxideSolvent

Procedure

0.8 g of methyl 3-[1-(4-(5-methoxycarbonylindol-3-yl)butyl)-4-piperidyl]indole-5-carboxylate [obtainable according to Example 1] is boiled for 0.5 h with 100 ml of 2N ethanolic KOH, worked up in a conventional manner and 3-[1-(4-(5-carboxyindol-3-yl)butyl)-4-piperidyl]-indole-5-carboxylic acid is obtained.

Sources & evidence

ORD record
ord-1cd6e6d1196b4052a5c0cb9e155ac10d
Source dataset
uspto-grants-1997_12
Patent number
US05693655

Reaction notes

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