Ethyl acetate hexane → HCID 69852121, compound

HRID 1938374Notes

Reaction equation

HRID 1938374 reaction equation
[F:1][C:2]1[C:11]2[C:12]3[CH:13]=[CH:14][C:15]([F:20])=[CH:16][C:17]=3[C:18](=O)[C:10]=2[CH:9]=[C:8]2[C:3]=1C(C)=CC(C)(C)[NH:7]2.CCCCCC.CC[O:32]C(C)=O>>[NH2:7][C:8]1[C:9](=[O:32])[C:10]2[C:11](=[C:2]([F:1])[CH:3]=1)[C:12]1[C:17](=[CH:16][C:15]([F:20])=[CH:14][CH:13]=1)[CH:18]=2

Participants

3

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 23433633HCID 23433633, compound

Product 1

HCID 69852121HCID 69852121, compound

Procedure

This compound was prepared according to General Method 3 (EXAMPLE 16) from Compound 132 (1.0 g, 4.6 mmol) to afford 5,8-difluoro-1,2-dihydro-2,2,4-trimethyl-10-oxoindeno[1,2-g]quinoline (structure 19 of Scheme VI, where R2, R5 =F, R3-4, R6 =H). Data for 5,8-difluoro-1,2-dihydro-2,2,4-trimethyl-10-oxoindeno[1,2-g]quinoline: Rf =0.49 (silca gel, hexane/EtOAc, 3:1), 1H NMR (400 MHz, acetone-d6) 7.50 (dd, J=8.1, 4.6, 1 H), 7.27 (m, 2 H), 6.73 (s, 1 H), 6.03 (br s, 1 H), 5.47 (s, 1 H), 2.16 (dd, J=7.1, 1.5, 3 H), 1.29 (s, 6 H).

Sources & evidence

ORD record
ord-b012eb2a06324673a572e601f1e1cd9c
Source dataset
uspto-grants-1997_12
Patent number
US05693646

Reaction notes

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