HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl borate → (3-Chloro-2-methoxyphenyl)boronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl borate | HCID 8470 | — |
| Reactant | 5-Fluoro-2-methoxyphenylboronic acid | HCID 2782673 | — |
| Reactant | 1-Bromo-3-chloro-2-methoxybenzene | HCID 23433617 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | (3-Chloro-2-methoxyphenyl)boronic acid | HCID 15766875 | 91% |
Reaction Steps
This compound was prepared in a manner similar to that of 5-fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 2-bromo-6-chloroanisole (0.71 g, 3.2 mmol), n-BuLi (2.5M in hexanes; 1.28 mL, 3.2 mmol), and trimethylborate (1.09 mL, 9.6 mmol) to afford 0.55 g (91%) of 3-chloro-2-methoxyphenylboronic acid which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693646 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-7e14aeef38e94a5ab3c7410ca3c33986 |
| Source note | uspto-grants-1997_12 |