HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trimethyl borate → (2-Methoxy-5-methylphenyl)boronic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trimethyl borate | HCID 8470 | — |
| Reactant | 2-Bromo-4-methylanisole | HCID 89143 | — |
| Reactant | 5-Fluoro-2-methoxyphenylboronic acid | HCID 2782673 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | (2-Methoxy-5-methylphenyl)boronic acid | HCID 2773485 | 96% |
Reaction Steps
This compound was prepared in a manner similar to that of 5-fluoro-2-methoxyphenylboronic acid (EXAMPLE 107) from 2-bromo-4-methylanisole (2.00 g, 9.94 mmol), n-BuLi (2.5M in hexanes; 4.00 mL, 10 mmol), and trimethylborate (3.4 mL, 30 mmol) to afford 1.60 g (96%) of 2-methoxy-5-methylphenylboronic acid which was used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693647 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-10da1655ecff44aa83211cbe33d5ed50 |
| Source note | uspto-grants-1997_12 |