Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 4-((3,4-(Methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Benzo-1,3-dioxole-5-methylamine | HCID 75799 | — |
| 반응물 | 4-Chloro-6,7,8-trimethoxyquinazoline | HCID 100686 | — |
| 용매 | Isopropanol | HCID 3776 | — |
| 생성물 | 4-((3,4-(Methylenedioxy)benzyl)amino)-6,7,8-trimethoxyquinazoline | HCID 205964 | 69.5% |
반응 단계
21.2 g (0.083 mol) of 4-chloro-6,7,8-trimethoxyquinazoline, 17.0 g (0.112 mol) of piperonylamine and 13.5 g (0.127 mol) of sodium carbonate were mixed with 400 ml of isopropyl alcohol. The obtained mixture was heated under reflux for 24 hours and distilled under a reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (ethyl acetate) and recrystallized from ethyl acetate to give 21.3 g of the title compound as a pale-yellow needle.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05693652 |
| 출처 데이터셋 | uspto-grants-1997_12 |
| ORD ID | ord-fc0388eb482446ab932bcd40631faa53 |
| 출처 메모 | uspto-grants-1997_12 |