HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → 2-Chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | Benzo-1,3-dioxole-5-methylamine | HCID 75799 | — |
| Reactant | 2,4-Dichloroquinazoline-6-carbonitrile | HCID 18796670 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-Chloro-4-(3,4-methylenedioxybenzyl)amino-6-cyanoquinazoline | HCID 21183984 | 79.4% |
Reaction Steps
35 ml of isopropyl alcohol, 900 mg of triethylamine and 1.35 g of piperonylamine were added to 2 g of 2,4-dichloro-6-cyanoquinazoline. The obtained mixture was heated under reflux for 1.5 hours and hot-filtered to recover a precipitate. Thus, 2.4 g of the title compound was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693652 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-286a7eff1db645feab93cb0b2b3dbc53 |
| Source note | uspto-grants-1997_12 |