Ethanol hydrochloric acid ethanol → 2-(4-Ethoxycarbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline hydrochloride

HRID 1938546Notes

Reaction equation

HRID 1938546 reaction equation
[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:21]=[C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]4[O:30][CH2:31][O:32][C:26]=4[CH:25]=3)[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([Cl:33])[CH:18]=3)[N:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2].C(O)C.Cl.C(O)C>>[ClH:33].[CH2:1]([O:3][C:4]([CH:6]1[CH2:11][CH2:10][N:9]([C:12]2[N:21]=[C:20]([NH:22][CH2:23][C:24]3[CH:29]=[CH:28][C:27]4[O:30][CH2:31][O:32][C:26]=4[CH:25]=3)[C:19]3[C:14](=[CH:15][CH:16]=[C:17]([Cl:33])[CH:18]=3)[N:13]=2)[CH2:8][CH2:7]1)=[O:5])[CH3:2]

Participants

3

Reactant 2

HCID 20213844Ethanol hydrochloric acid ethanolHCID 211838922-(4-Ethoxycarbonylpiperidino)-4-(3,4-methylenedioxy-benzyl)amino-6-chloroquinazoline

Product 1

HCID 211839052-(4-Ethoxycarbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline hydrochloride

Procedure

The title compound was prepared from the 2-(4-Ethoxycarbonylpiperidino)-4-(3,4-methylenedioxybenzyl)amino-6-chloroquinazoline prepared in Example 205 by the use of ethanol-hydrochloric acid-ethanol.

Sources & evidence

ORD record
ord-f397bd22d1754b7e809640cabf756e57
Source dataset
uspto-grants-1997_12
Patent number
US05693652

Reaction notes

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