HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 2-(4-Ethoxycarbonylpiperidino)-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | 2-Chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline | HCID 21184004 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | 2-(4-Ethoxycarbonylpiperidino)-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline | HCID 21183926 | 84.6% |
Reaction Steps
3.5 g of ethyl isonipecotate, 2.25 g of triethylamine and 30 ml of 2-propanol were added to 1 g of 2-chloro-4-(3-chloro-4-methoxybenzyl)amino-6-cyanoquinazoline. The obtained mixture was refluxed for 30 minutes and cooled to room temperature. The crystals thus precipitated were recovered by filtration and washed with water and ethanol successively to give 1.13 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05693652 |
| Source dataset | uspto-grants-1997_12 |
| ORD ID | ord-ce05d2105b7c42c59f714293202bf3fa |
| Source note | uspto-grants-1997_12 |