Acetyl chloride → N-[2-(5-methyl-1H-indol-3-yl)ethyl]acetamide

HRID 1938567Notes

Reaction equation

[CH3:1][C:2]1[CH:13]=[C:12]2[C:5]([NH:6][CH:7]=[C:8]2[CH2:9][CH2:10][NH2:11])=[CH:4][CH:3]=1.[C:14](Cl)(=[O:16])[CH3:15]>>[CH3:1][C:2]1[CH:13]=[C:12]2[C:5](=[CH:4][CH:3]=1)[NH:6][CH:7]=[C:8]2[CH2:9][CH2:10][NH:11][C:14](=[O:16])[CH3:15]

Participants

Reactant 2

HCID 6367Acetyl chloride

HCID 157605-Methyltryptamine

Product 1

HCID 699129N-[2-(5-methyl-1H-indol-3-yl)ethyl]acetamide

Procedure

Working in the same manner as for the amidation reaction of Example 1, but using 5-methyltryptamine (Preparation 6) and acetyl chloride as reactants, the title compound is obtained.

Workup

customWorking in the same manner as for the amidation reaction of Example 1

Sources & evidence

ORD record: ord-80a24f24cd5c462aaf9da1b9691c46cf
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05693665

Reaction notes

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